Biotin

Biotin

SCHEMBL1523072

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CC(S(=O)(=O)O)C(=O)N1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 5/20 0.71
MEN1 O00255 1/20 0.71
ABL1 P00519 1/20 0.71
LMNA P02545 1/20 0.71
PKM P14618 1/20 0.71
IDE P14735 1/20 0.71
MAPK1 P28482 1/20 0.71
KMT2A Q03164 1/20 0.71
RIN1 Q13671 1/20 0.71
L3MBTL1 Q9Y468 1/20 0.71
HLCS P50747 6/20 0.51
CA12 O43570 8/20 0.48
CA1 P00915 8/20 0.48
CA2 P00918 8/20 0.48
CA9 Q16790 8/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3740873 0.92 TDP1 (0.61) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL28780778 0.87 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1215022 0.87 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL5503948 0.86 TDP1 (0.76) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL2456558 0.86 TDP1 (0.76) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL4433162 0.85 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL6648954 0.84 TDP1 (0.85) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL2847993 0.84 TDP1 (0.85) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 0.84 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL22943835 0.84 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119768425-A Anti-TL 1A antibodies and methods of use thereof 辉瑞大药厂 2025-04-04 CN disclosed
US-9523683-B2 Functionalized polydiacetylene sensors THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2016-12-20 US disclosed
US-20150268232-A1 Functionalized Polydiacetylene Sensors THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2015-09-24 US disclosed
US-8633140-B2 Functionalized polydiacetylene sensors THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2014-01-21 US disclosed
US-8318696-B2 Polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative SANOFI (FR) 2012-11-27 US disclosed
US-20110144042-A1 Novel Polysaccharides with Antithrombotic Activity Comprising at Least One Covalent Bond with Biotin or a Biotin Derivative SANOFI-AVENTIS (FR) 2011-06-16 US disclosed
US-7943595-B2 Polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative SANOFI-AVENTIS (FR) 2011-05-17 US disclosed
US-20110059867-A1 FUNCTIONALIZED POLYDIACETYLENE SENSORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2011-03-10 US disclosed
US-20060160768-A1 Novel polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative SANOFI (FR) 2006-07-20 US disclosed
US-6844329-B2 Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative SANOFI-SYNTHELABO (FR) 2005-01-18 US disclosed
US-20040180381-A1 Method for determining amino acid sequence of a peptide SHIMADZU CORPORATION (JP) 2004-09-16 US disclosed
US-20040024197-A1 Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative SANOFI (FR) 2004-02-05 US disclosed
EP-0817617-B1 MICROCAPSULES OF PREDETERMINED PEPTIDE(S) SPECIFICITY(IES), THEIR PREPARATION AND USES UNIV TEMPLE (US) 2003-05-14 EP disclosed
EP-0817617-A4 MICROCAPSULES OF PREDETERMINED PEPTIDE(S) SPECIFICITY(IES), THEIR PREPARATION AND USES UNIV TEMPLE (US) 1999-01-27 EP disclosed
EP-0817617-A1 MICROCAPSULES OF PREDETERMINED PEPTIDE(S) SPECIFICITY(IES), THEIR PREPARATION AND USES TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 1998-01-14 EP disclosed
US-5686113-A Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 1997-11-11 US disclosed
WO-1996029059-A9 MICROCAPSULES OF PREDETERMINED PEPTIDE(S) SPECIFICITY(IES), THEIR PREPARATION AND USES 1996-11-21 WO disclosed
WO-1996029059-A1 MICROCAPSULES OF PREDETERMINED PEPTIDE(S) SPECIFICITY(IES), THEIR PREPARATION AND USES TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 1996-09-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160768-A1 Novel polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative SERPINC1, SELP, FGB TDP1 2935/4885MEN1 3047/4885ABL1 4875/4885
US-20040180381-A1 Method for determining amino acid sequence of a peptide VIP, ANPEP, DNPEP TDP1 2820/4885MEN1 940/4885ABL1 2829/4885
US-20040024197-A1 Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative SERPINC1, SELP, FGB TDP1 2881/4885MEN1 2426/4885ABL1 4857/4885
US-20110059867-A1 FUNCTIONALIZED POLYDIACETYLENE SENSORS STUB1, PA2G4, SUMO2 TDP1 3652/4885MEN1 4390/4885ABL1 2213/4885
US-20110144042-A1 Novel Polysaccharides with Antithrombotic Activity Comprising at Least One Covalent Bond with Biotin or a Biotin Derivative SERPINC1, SELP, FGB TDP1 2935/4885MEN1 3047/4885ABL1 4875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.