Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023398 | 0.76 | NOS1 (0.35) | — | |
| SCHEMBL1023547 | 0.76 | MAPT (0.44) | NPC1ALDH1A1MAPTGFERHSD17B10 | |
| SCHEMBL8079826 | 0.65 | — | — | |
| SCHEMBL29764 | 0.62 | NPC1 (0.52) | NPC1ALDH1A1MAPTGFERHSD17B10 | |
| SCHEMBL546076 | 0.61 | PDPK1 (0.35) | — | |
| SCHEMBL12982161 | 0.60 | NPC1 (0.50) | NPC1ALDH1A1MAPTGFERHSD17B10 | |
| SCHEMBL12170048 | 0.60 | NPC1 (0.50) | NPC1ALDH1A1MAPTGFERHSD17B10 | |
| SCHEMBL12982405 | 0.60 | NPC1 (0.50) | NPC1ALDH1A1MAPTGFERHSD17B10 | |
| SCHEMBL120939 | 0.60 | NPC1 (0.50) | NPC1ALDH1A1MAPTGFERHSD17B10 | |
| SCHEMBL11997754 | 0.60 | NPC1 (0.50) | NPC1ALDH1A1MAPTGFERHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8212014-B2 | Artificial base pairs and uses thereof | RIKEN (JP) | 2012-07-03 | — | — | US | claimed |
| EP-1921141-B1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | RIKEN (JP) | 2011-01-12 | — | — | EP | claimed |
| US-20100323364-A1 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2010-12-23 | — | — | US | claimed |
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | RIKEN (JP) | 2010-11-11 | — | — | US | claimed |
| EP-2246428-A1 | MODIFIED TRNA CONTAINING NON-NATURAL NUCLEOTIDE AND USE THEREOF | The University of Tokyo (JP) | 2010-11-03 | — | — | EP | claimed |
| EP-1921141-A1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | Riken (JP) | 2008-05-14 | — | — | EP | claimed |
| US-8715984-B2 | Modified tRNA containing unnatural base and use thereof | RIKEN (JP) | 2014-05-06 | — | — | US | disclosed |
| US-8212014-B2 | Artificial base pairs and uses thereof | RIKEN (JP) | 2012-07-03 | — | — | US | disclosed |
| EP-1921141-B1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | RIKEN (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-20100323364-A1 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | RIKEN (JP) | 2010-11-11 | — | — | US | disclosed |
| EP-2246428-A1 | MODIFIED TRNA CONTAINING NON-NATURAL NUCLEOTIDE AND USE THEREOF | The University of Tokyo (JP) | 2010-11-03 | — | — | EP | disclosed |
| EP-1921141-A1 | NOVEL ARTIFICIAL BASE PAIR AND USE THEREOF | Riken (JP) | 2008-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100285598-A1 | Novel Artificial Base Pairs and Uses Thereof | POLRMT, RNGTT, POLN | NPC1 3586/4885ALDH1A1 3557/4885MAPT 4470/4885 |
| US-20100323364-A1 | MODIFIED tRNA CONTAINING UNNATURAL BASE AND USE THEREOF | TRMT1, NSUN3, TARBP1 | NPC1 3289/4885ALDH1A1 3848/4885MAPT 2146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.