Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.51 |
| ▸ | MMP9 | P14780 | 16/20 | 0.51 |
| ▸ | MMP14 | P50281 | 12/20 | 0.51 |
| ▸ | MMP3 | P08254 | 8/20 | 0.51 |
| ▸ | MMP8 | P22894 | 4/20 | 0.51 |
| ▸ | MMP7 | P09237 | 3/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238436 | 0.82 | MMP2 (0.60) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL10238442 | 0.79 | MMP2 (0.53) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL315578 | 0.74 | MMP2 (0.65) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL12747850 | 0.68 | HSD17B1 (0.41) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL2684163 | 0.68 | MMP2 (1.00) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL10238412 | 0.68 | MMP2 (0.56) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL11869356 | 0.67 | TSPO (0.62) | TSPOSLC6A2SLC6A4 | |
| SCHEMBL12746771 | 0.66 | MMP2 (0.44) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL2380308 | 0.65 | MMP2 (0.76) | MMP2MMP9MMP14MMP3MMP8 | |
| SCHEMBL10239046 | 0.65 | MMP2 (0.71) | MMP2MMP9MMP14MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093287-B2 | Inhibitors of matrix metalloproteinases | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | NOTRE DAME UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
| US-7928127-B2 | Inhibitors of matrix metallaproteinases | NOTRE DAME UNIVERSITY (US) | 2011-04-19 | — | — | US | disclosed |
| US-20090005420-A1 | Inhibitors of Matrix Metallaproteinases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005420-A1 | Inhibitors of Matrix Metallaproteinases | MMP9, MMP1, MMP2 | MMP2 3/4885MMP9 1/4885MMP14 15/4885 |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | MMP9, MMP1, MMP2 | MMP2 3/4885MMP9 1/4885MMP14 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.