Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 18/20 | 0.48 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4523520 | 0.99 | ACLY (0.51) | ACLYHTR6CCKBRADRA2A | |
| SCHEMBL1421966 | 0.85 | ACLY (0.56) | ACLYHTR6CCKBR | |
| SCHEMBL14290796 | 0.85 | ACLY (0.56) | ACLYHTR6CCKBRADRA2A | |
| SCHEMBL10240490 | 0.83 | ACLY (0.47) | ACLYHTR6CCKBR | |
| SCHEMBL10238843 | 0.82 | ACLY (0.52) | ACLYHTR6CCKBRADRA2A | |
| Hydrochloric Acid SCHEMBL9958746 | 0.82 | ACLY (0.47) | ACLYHTR6CCKBR | |
| SCHEMBL4031340 | 0.82 | ACLY (0.47) | ACLYHTR6CCKBRADRA2A | |
| SCHEMBL4022458 | 0.82 | ACLY (0.45) | ACLYHTR6CCKBRADRA2A | |
| SCHEMBL730731 | 0.81 | HTR6 (0.48) | ACLYHTR6CCKBRADRA2A | |
| SCHEMBL748742 | 0.81 | HTR6 (0.48) | ACLYHTR6CCKBRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, HTR5A, HTR7 | ACLY 4043/4885HTR6 1/4885CCKBR 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.