Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | PNMT | P11086 | 5/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9958689 | 0.99 | HTR6 (0.47) | HTR6PNMTGHSRCCKBRPDPK1 | |
| SCHEMBL10239550 | 0.91 | HTR6 (0.46) | HTR6PNMTGHSRCCKBRPDPK1 | |
| Hydrochloric Acid SCHEMBL9956941 | 0.90 | HTR6 (0.45) | HTR6PNMTGHSRCCKBRPDPK1 | |
| SCHEMBL10238852 | 0.81 | HTR6 (0.51) | HTR6PNMTGHSRPRCPALDH1A1 | |
| Hydrochloric Acid SCHEMBL9960332 | 0.81 | HTR6 (0.50) | HTR6PNMTGHSRPRCPALDH1A1 | |
| SCHEMBL10239559 | 0.79 | PNMT (0.47) | HTR6PNMTGHSRPRCPADRA2A | |
| SCHEMBL10238650 | 0.79 | PNMT (0.46) | PNMTGHSRPRCPALDH1A1 | |
| SCHEMBL10238666 | 0.78 | CCKBR (0.44) | HTR6GHSRCCKBRPDPK1CCR1 | |
| SCHEMBL13757765 | 0.78 | HTR6 (0.52) | HTR6PNMTGHSRCCKBRPDPK1 | |
| Hydrochloric Acid SCHEMBL9960120 | 0.78 | PNMT (0.46) | HTR6PNMTGHSRPRCPADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, HTR5A, HTR7 | HTR6 1/4885PNMT 35/4885GHSR 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.