Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.55 |
| ▸ | HTR6 | P50406 | 5/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9959470 | 0.99 | PNMT (0.54) | PNMTHTR6WDR5HTR2CDRD2 | |
| SCHEMBL13757767 | 0.95 | HTR6 (0.53) | PNMTHTR6WDR5HTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL9959618 | 0.94 | HTR6 (0.52) | PNMTHTR6WDR5HTR2CDRD2 | |
| SCHEMBL3354766 | 0.93 | HTR6 (0.55) | PNMTHTR6WDR5HTR2CDRD2 | |
| SCHEMBL10238848 | 0.93 | PNMT (0.55) | PNMTHTR6WDR5HTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL9960393 | 0.92 | PNMT (0.54) | PNMTHTR6WDR5HTR2CDRD2 | |
| SCHEMBL13757778 | 0.89 | HTR6 (0.52) | PNMTHTR6WDR5HTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL9960365 | 0.88 | HTR6 (0.51) | PNMTHTR6WDR5HTR2CDRD2 | |
| SCHEMBL10240571 | 0.86 | HTR6 (0.53) | PNMTHTR6HTR2CDRD2HTR2A | |
| SCHEMBL10239980 | 0.86 | HTR6 (0.53) | PNMTHTR6HTR2CDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, HTR5A, HTR7 | PNMT 35/4885HTR6 1/4885WDR5 2888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.