Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | PNMT | P11086 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 7/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9959737 | 0.99 | HTR6 (0.52) | HTR6PNMTHTR2CDRD2HTR2A | |
| SCHEMBL13757764 | 0.95 | HTR6 (0.53) | HTR6PNMTHTR2CDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9960336 | 0.94 | HTR6 (0.52) | HTR6PNMTHTR2CDRD2HTR2A | |
| SCHEMBL10239980 | 0.86 | HTR6 (0.53) | HTR6PNMTHTR2CDRD2HTR2A | |
| SCHEMBL10240580 | 0.86 | PNMT (0.55) | HTR6PNMTHTR2CDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9959470 | 0.85 | PNMT (0.54) | HTR6PNMTHTR2CDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9960329 | 0.85 | HTR6 (0.52) | HTR6PNMTHTR2CDRD2HTR2A | |
| SCHEMBL10238657 | 0.84 | HTR6 (0.55) | HTR6PNMTHTR2CDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9960412 | 0.83 | HTR6 (0.54) | HTR6PNMTHTR2CDRD2HTR2A | |
| SCHEMBL3351109 | 0.83 | FABP4 (0.43) | FABP4FABP5BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, HTR5A, HTR7 | HTR6 1/4885PNMT 35/4885HTR2C 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.