Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175202 | 0.81 | HTR1A (0.60) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL30511844 | 0.80 | MTNR1A (0.64) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL24010334 | 0.79 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL24010540 | 0.79 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL5759973 | 0.77 | LMNA (0.78) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL2699530 | 0.76 | MTNR1A (0.54) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL29430303 | 0.76 | CYP1A2 (0.54) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL30682081 | 0.76 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL3727852 | 0.76 | HTR1A (0.49) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL29878429 | 0.75 | MET (0.54) | HTR1AADRA1DADRA1AADRA1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120107275-A1 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120107275-A1 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE | HGF, HGFAC, MET | HTR1A 3988/4885ADRA1D 3392/4885ADRA1A 3022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.