Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350750 | 1.00 | HSD11B1 (0.53) | HSD11B1DRD2DRD4GRM5SLC18A3 | |
| SCHEMBL17350581 | 0.89 | HSD11B1 (0.50) | HSD11B1DRD2DRD4SLC18A3SIGMAR1 | |
| SCHEMBL10244021 | 0.89 | HSD11B1 (0.50) | HSD11B1DRD2DRD4SLC18A3SIGMAR1 | |
| SCHEMBL10243820 | 0.86 | MGLL (0.48) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL17350639 | 0.86 | MGLL (0.48) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL10244083 | 0.85 | SLC18A3 (0.46) | HSD11B1DRD2DRD4SLC18A3SIGMAR1 | |
| SCHEMBL17350839 | 0.85 | OPRM1 (0.53) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL17350616 | 0.85 | SLC18A3 (0.46) | HSD11B1DRD2DRD4SLC18A3SIGMAR1 | |
| SCHEMBL10244342 | 0.85 | OPRM1 (0.53) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL10243864 | 0.85 | HSD11B1 (0.53) | HSD11B1DRD2DRD4SLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885DRD2 772/4885DRD4 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.