Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350839 | 1.00 | OPRM1 (0.53) | OPRM1OPRD1PARP14PARP10PARP1 | |
| SCHEMBL10244021 | 0.89 | HSD11B1 (0.50) | PARP14PARP10SLC18A3SIGMAR1KDM1A | |
| SCHEMBL17350581 | 0.89 | HSD11B1 (0.50) | PARP14PARP10SLC18A3SIGMAR1KDM1A | |
| SCHEMBL10244083 | 0.88 | SLC18A3 (0.46) | OPRM1OPRD1PARP14PARP10SLC18A3 | |
| SCHEMBL17350616 | 0.88 | SLC18A3 (0.46) | OPRM1OPRD1PARP14PARP10SLC18A3 | |
| SCHEMBL10243437 | 0.87 | PARP10 (0.56) | OPRM1OPRD1PARP14PARP10SLC18A3 | |
| SCHEMBL17350989 | 0.87 | PARP10 (0.56) | OPRM1OPRD1PARP14PARP10SLC18A3 | |
| SCHEMBL10243820 | 0.86 | MGLL (0.48) | OPRM1OPRD1PARP14PARP10SLC18A3 | |
| SCHEMBL17350639 | 0.86 | MGLL (0.48) | OPRM1OPRD1PARP14PARP10SLC18A3 | |
| SCHEMBL10243928 | 0.85 | HSD11B1 (0.53) | SLC18A3SIGMAR1DRD2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | HSD11B1, HSD11B2, HSD17B1 | OPRM1 1008/4885OPRD1 337/4885PARP14 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.