Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570537 | 0.94 | NLRP3 (0.61) | NLRP3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL9359788 | 0.90 | NLRP3 (0.78) | NLRP3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL1026418 | 0.89 | MAPK1 (0.72) | NLRP3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL1024875 | 0.86 | MAPK1 (0.61) | NLRP3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL1023754 | 0.85 | MAPK1 (0.60) | NLRP3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL1955909 | 0.85 | NLRP3 (0.80) | NLRP3ALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL30593915 | 0.84 | NPC1 (0.71) | NLRP3ALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL69360 | 0.84 | NPC1 (0.71) | NLRP3ALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL1023162 | 0.84 | HPGD (0.50) | NLRP3ALDH1A1HPGDMAPK1NPC1 | |
| SCHEMBL1025186 | 0.84 | MAPK1 (0.59) | NLRP3ALDH1A1HPGDMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5201953-A | — | — | None | — | — | JP | disclosed |
| US-9637445-B2 | Isocyanate production process using composition containing carbamic acid ester and aromatic hydroxy compound, and composition for transfer and storage of carbamic acid ester | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2017-05-02 | — | — | US | disclosed |
| EP-2147909-B1 | METHOD FOR PRODUCTION OF ISOCYANATE USING COMPOSITION COMPRISING CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND, AND COMPOSITION FOR TRANSPORT OR STORAGE OF CARBAMIC ACID ESTER | ASAHI CHEMICAL IND (JP) | 2016-12-14 | — | — | EP | disclosed |
| US-20150259279-A1 | Isocyanate Production Process Using Composition Containing Carbamic Acid Ester and Aromatic Hydroxy Compound, and Composition for Transfer and Storage of Carbamic Acid Ester | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2015-09-17 | — | — | US | disclosed |
| US-9056819-B2 | Isocyanate production process using composition containing carbamic acid ester and aromatic hydroxy compound, and composition for transfer and storage of carbamic acid ester | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2015-06-16 | — | — | US | disclosed |
| EP-2088138-B1 | Process for producing isocyanate | ASAHI KASEI CHEMICALS CORP (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-8362293-B2 | Process for producing isocyanates | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2013-01-29 | — | — | US | disclosed |
| US-8053595-B2 | Process for producing isocyanates | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2011-11-08 | — | — | US | disclosed |
| EP-2088137-B1 | A PROCESS FOR PRODUCING ISOCYANATES | ASAHI KASEI CHEMICALS CORP (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-20100113823-A1 | ISOCYANATE PRODUCTION PROCESS USING COMPOSITION CONTAINING CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND, AND COMPOSITION FOR TRANSFER AND STORAGE OF CARBAMIC ACID ESTER | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100069665-A1 | PROCESS FOR PRODUCING ISOCYANATES | AHAHI KASEI CHEMICALS CORPORATION (JP) | 2010-03-18 | — | — | US | disclosed |
| US-20100029981-A1 | PROCESS FOR PRODUCING ISOCYANATES | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-2147909-A1 | METHOD FOR PRODUCTION OF ISOCYANATE USING COMPOSITION COMPRISING CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND, AND COMPOSITION FOR TRANSPORT OR STORAGE OF CARBAMIC ACID ESTER | Asahi Kasei Chemicals Corporation (JP) | 2010-01-27 | — | — | EP | disclosed |
| EP-2088137-A1 | METHOD FOR PRODUCING ISOCYANATE | Asahi Kasei Chemicals Corporation (JP) | 2009-08-12 | — | — | EP | disclosed |
| EP-2088138-A1 | PROCESS FOR PRODUCING ISOCYANATE | Asahi Kasei Chemicals Corporation (JP) | 2009-08-12 | — | — | EP | disclosed |
| US-20090082588-A1 | Process for producing fluorinated carbamates and isocyanates | REPSOL YPF, S.A. (ES) | 2009-03-26 | — | — | US | disclosed |
| EP-2036884-A1 | Process for producing fluorinated isocyanates and carbamates | REPSOL YPF S.A. (ES) | 2009-03-18 | — | — | EP | disclosed |
| JP-H05201953-A | PRODUCTION OF BIS-(ETHOXYCARBONYL-AMINO)-TOLUENE AND PROCESS FOR PRODUCING DIISOCYANATETOLUENE THEREFROM | BAYER AG | 1993-08-10 | — | — | JP | disclosed |
| EP-0520273-A2 | Process for the preparation of bis(ethoxycarbonylamino) toluols and their use in the preparation of diisocyanato toluols | BAYER AG (DE) | 1992-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113823-A1 | ISOCYANATE PRODUCTION PROCESS USING COMPOSITION CONTAINING CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND, AND COMPOSITION FOR TRANSFER AND STORAGE OF CARBAMIC ACID ESTER | PAH, APEH, CPS1 | NLRP3 472/4885ALDH1A1 2908/4885HPGD 304/4885 |
| US-20100029981-A1 | PROCESS FOR PRODUCING ISOCYANATES | PAH, ALKBH3, GRHPR | NLRP3 2178/4885ALDH1A1 906/4885HPGD 299/4885 |
| US-20100069665-A1 | PROCESS FOR PRODUCING ISOCYANATES | CPS1, IDH2, PHGDH | NLRP3 3782/4885ALDH1A1 1960/4885HPGD 22/4885 |
| US-20090082588-A1 | Process for producing fluorinated carbamates and isocyanates | SRM, CA4, PRMT3 | NLRP3 3415/4885ALDH1A1 2517/4885HPGD 3661/4885 |
| US-20150259279-A1 | Isocyanate Production Process Using Composition Containing Carbamic Acid Ester and Aromatic Hydroxy Compound, and Composition for Transfer and Storage of Carbamic Acid Ester | PAH, APEH, CPS1 | NLRP3 472/4885ALDH1A1 2908/4885HPGD 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.