Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | XIAP | P98170 | 3/20 | 0.39 |
| ▸ | CCKBR | P32239 | 3/20 | 0.38 |
| ▸ | TGM2 | P21980 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646141 | 1.00 | DRD4 (0.41) | DRD4XIAPCCKBRTGM2CASP1 | |
| SCHEMBL10262993 | 0.87 | CCKBR (0.38) | DRD4XIAPCCKBR | |
| SCHEMBL645107 | 0.82 | XIAP (0.46) | XIAPCASP1 | |
| SCHEMBL12444043 | 0.80 | CASP1 (0.52) | XIAPCCKBRCASP1 | |
| SCHEMBL647286 | 0.80 | CASP1 (0.52) | XIAPCCKBRCASP1 | |
| SCHEMBL10249426 | 0.80 | CASP1 (0.52) | XIAPCCKBRCASP1 | |
| SCHEMBL10251968 | 0.78 | CASP1 (0.45) | XIAPCASP1 | |
| SCHEMBL10200303 | 0.78 | CASP1 (0.45) | XIAPCASP1 | |
| SCHEMBL12443659 | 0.78 | CASP1 (0.45) | XIAPCASP1 | |
| SCHEMBL10201727 | 0.76 | XIAP (0.40) | XIAPCCKBRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119631-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110178069-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178069-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | IL1A, IFNAR1, IL1B | DRD4 4736/4885XIAP 257/4885CCKBR 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.