Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076529 | 0.82 | IDH1 (0.42) | LMNAKDM4EMEN1NPC1MAPT | |
| SCHEMBL1026191 | 0.81 | MAOA (0.50) | MEN1KMT2ACYP19A1ALDH1A1 | |
| SCHEMBL1024314 | 0.80 | JAK1 (0.43) | — | |
| SCHEMBL13669912 | 0.79 | KIF18A (0.38) | LMNAKDM4EMEN1NPC1MAPT | |
| SCHEMBL13622732 | 0.77 | KAT6A (0.41) | — | |
| SCHEMBL1026817 | 0.72 | CYP4F2 (0.44) | LMNAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1027535 | 0.72 | MAOA (0.39) | LMNAKDM4EMEN1MAPTHPGD | |
| SCHEMBL1026509 | 0.71 | CYP1A2 (0.36) | LMNAMEN1NPC1MAPTRAB9A | |
| SCHEMBL1026880 | 0.71 | THRA (0.39) | KMT2AALDH1A1NPSR1 | |
| SCHEMBL666092 | 0.71 | LOXL2 (0.43) | LMNAMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |