Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | BRD4 | O60885 | 8/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | BCL6 | P41182 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341601 | 0.88 | JAK1 (0.47) | JAK1HDAC1BRD4NUAK1JAK2 | |
| SCHEMBL13622734 | 0.83 | JAK1 (0.45) | JAK1HDAC1BRD4NUAK1JAK2 | |
| SCHEMBL1026264 | 0.80 | LMNA (0.36) | — | |
| SCHEMBL1027178 | 0.80 | JAK2 (0.41) | JAK1HDAC1BRD4JAK2JAK3 | |
| SCHEMBL1026395 | 0.79 | BCL6 (0.40) | JAK1HDAC1JAK3BTKBCL6 | |
| SCHEMBL1023949 | 0.79 | ALDH1A1 (0.40) | JAK3BTKBCL6 | |
| SCHEMBL1026953 | 0.79 | GAA (0.47) | BTKBCL6 | |
| SCHEMBL1025665 | 0.79 | JAK1 (0.45) | JAK1HDAC1BRD4NUAK1BTK | |
| SCHEMBL1027670 | 0.78 | BCL6 (0.38) | JAK3BTKBCL6 | |
| SCHEMBL1025116 | 0.78 | MET (0.41) | JAK1HDAC1JAK2JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |