Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL1026532

CC(=O)N(Cc1cccc(N)c1)Cc1cccc(N(C(=O)O)C(C)(C)C)c1.O=C(O)C(F)(F)F

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
KMT2A Q03164 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALDH1A1 P00352 2/20 0.36
TSPO P30536 1/20 0.36
HSD11B1 P28845 1/20 0.35
SLC2A1 P11166 1/20 0.35
OPRM1 P35372 8/20 0.34
OPRD1 P41143 8/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
GRM2 Q14416 1/20 0.33
GRM3 Q14832 1/20 0.33
HTR5A P47898 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1026533 0.84 HSD11B1 (0.33) CRHBPCRHR2SLC6A2SLC6A4SLC6A3
SCHEMBL1026191 0.81 MAOA (0.50) CRHBPCRHR2KMT2AL3MBTL1ALDH1A1
Trifluoroacetic Acid SCHEMBL1026530 0.80 ALDH1A1 (0.44) L3MBTL1ALDH1A1SMN1; SMN2
Trifluoroacetic Acid SCHEMBL1023947 0.79 CTSC (0.38)
SCHEMBL1026509 0.78 CYP1A2 (0.36) CRHBPCRHR2KMT2AL3MBTL1ALDH1A1
SCHEMBL1026880 0.78 THRA (0.39) CRHBPCRHR2KMT2AL3MBTL1ALDH1A1
SCHEMBL1025247 0.77 CYP1A2 (0.50) CRHBPCRHR2KMT2AALDH1A1SLC2A1
SCHEMBL1025248 0.77 CYP1A2 (0.50) CRHBPCRHR2KMT2AALDH1A1SLC2A1
SCHEMBL1026693 0.77 ALDH1A1 (0.42) KMT2AALDH1A1SMN1; SMN2
SCHEMBL1027535 0.74 MAOA (0.39) KMT2AALDH1A1SMN1; SMN2GRM2GRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2274288-A2 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS Incyte Corporation (US) 2011-01-19 EP disclosed