Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLQ | O75417 | 2/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676809 | 0.88 | SIGMAR1 (0.56) | ITGB1ITGA4SIGMAR1ALDH1A1LMNA | |
| SCHEMBL1692108 | 0.84 | POLQ (0.45) | ITGB1ITGA4SIGMAR1ALDH1A1LMNA | |
| SCHEMBL14039474 | 0.82 | KMT2A (0.52) | SIGMAR1ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL8263373 | 0.82 | ALDH1A1 (0.58) | ALDH1A1LMNAROCK2ROCK1POLQ | |
| SCHEMBL1696796 | 0.81 | HTR1A (0.45) | SIGMAR1ROCK2ROCK1TP53RAB9A | |
| SCHEMBL18970326 | 0.81 | ITGB1 (0.48) | ITGB1ITGA4SIGMAR1ALDH1A1LMNA | |
| SCHEMBL1696949 | 0.79 | MEN1 (0.55) | SIGMAR1ALDH1A1NPC1RAB9A | |
| SCHEMBL1697001 | 0.78 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL1696343 | 0.77 | L3MBTL1 (0.55) | ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL20349603 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNANLRP3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | ITGB1 2172/4885ITGA4 1739/4885SIGMAR1 4349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.