Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14783522 | 0.84 | FAAH (0.50) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL6924040 | 0.81 | ALDH1A1 (0.51) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL11175838 | 0.81 | LMNA (0.57) | ALDH1A1CYP1A2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL9267073 | 0.80 | ALDH1A1 (0.52) | ALDH1A1CYP1A2KDM4EHPGDKMT2A | |
| SCHEMBL28962581 | 0.78 | ALDH1A1 (0.53) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL696908 | 0.77 | KMT2A (0.44) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL57245 | 0.77 | KMT2A (0.50) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL11339293 | 0.76 | FAAH (0.52) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL16918662 | 0.76 | FAAH (0.60) | FAAHALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL22289601 | 0.76 | ALDH1A1 (0.48) | FAAHALDH1A1CYP1A2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661432-B1 | PYRROLIDINE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | disclosed |
| US-8618303-B2 | Pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2661432-A1 | PYRROLIDINE DERIVATIVES AS NK3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-13 | — | — | EP | disclosed |
| US-20120178761-A1 | PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-12 | — | — | US | disclosed |
| WO-2012093109-A1 | PYRROLIDINE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178761-A1 | PYRROLIDINE DERIVATIVES | SLC6A3, NPSR1, TACR1 | FAAH 1738/4885ALDH1A1 377/4885CYP1A2 1491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.