Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390532 | 0.86 | ACACB (0.48) | ERN1GSK3BTAS1R3TAS1R1CYP3A4 | |
| SCHEMBL10280413 | 0.82 | ALDH1A1 (0.53) | ERN1NPC1RAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL10280160 | 0.78 | RARG (0.46) | RAB9AGSK3BDYRK1ACYP3A4CYP2D6 | |
| SCHEMBL14886670 | 0.76 | GSK3B (0.52) | ERN1NPC1RAB9ACLK1GSK3B | |
| SCHEMBL10460382 | 0.76 | MAPT (0.48) | SLC6A9NPC1RAB9AGSK3BSMN1; SMN2 | |
| SCHEMBL7922447 | 0.74 | TDP1 (0.51) | ERN1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL10459600 | 0.74 | CLK1 (0.43) | NPC1RAB9ACLK1SMN1; SMN2TAS1R3 | |
| SCHEMBL7923604 | 0.73 | CHEK1 (0.47) | ERN1SMN1; SMN2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7920254 | 0.72 | PLA2G2A (0.51) | CYP3A4CYP2D6TSHRALDH1A1MAPT | |
| SCHEMBL7928723 | 0.72 | PLA2G2A (0.50) | ERN1TSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010247-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010247-A1 | BICYCLIC COMPOUND | ACACA, CPT1B, ACACB | ERN1 3393/4885SLC6A9 2115/4885NPC1 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.