Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880317 | 0.86 | LMNA (0.43) | EEF2KALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL12162752 | 0.86 | CYP19A1 (0.49) | EEF2KALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL14047508 | 0.86 | EEF2K (0.44) | EEF2KALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL880279 | 0.81 | TP53 (0.46) | EEF2KALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL880430 | 0.77 | LMNA (0.67) | ALDH1A1KMT2ALMNASMN1; SMN2MAPK1 | |
| SCHEMBL12162742 | 0.75 | IDO1 (0.42) | EEF2KALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL12278879 | 0.75 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDLMNAMAPK1 | |
| SCHEMBL6001645 | 0.72 | RAB9A (0.49) | EEF2KALDH1A1KDM4ENPSR1LMNA | |
| SCHEMBL880443 | 0.69 | TP53 (0.76) | ALDH1A1KMT2AKDM4EMEN1HPGD | |
| SCHEMBL7154204 | 0.69 | WDR5 (0.45) | ALDH1A1KDM4ELMNAMAPK1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |