SCHEMBL1028516

SCHEMBL1028516

Nc1cc(Br)cc(C(=O)O)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
ALDH1A1 P00352 2/20 0.47
LMNA P02545 2/20 0.47
POLB P06746 2/20 0.47
HCAR2 Q8TDS4 1/20 0.47
DDO Q99489 1/20 0.47
TTR P02766 2/20 0.46
TPMT P51580 4/20 0.44
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
GLA P06280 1/20 0.41
TDP1 Q9NUW8 2/20 0.39
TP53 P04637 1/20 0.39
CA3 P07451 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30197207 1.00 KDM4E (0.47) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL7184528 0.84 PBRM1 (0.42) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL475757 0.83 TTR (0.56) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL2820215 0.83 KDM4E (0.56) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL109155 0.83 KDM4E (0.56) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL23501889 0.83 TTR (0.56) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL8361 0.83 TTR (0.56) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL223304 0.83 KDM4E (0.56) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL15484864 0.82 PARP1 (0.52) KDM4EMEN1KMT2AALDH1A1LMNA
Hydrochloric Acid SCHEMBL11153457 0.80 TTR (0.54) KDM4EMEN1KMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119751962-A Preparation method of heat radiation aerogel for lithium battery 广东宇阳新能源有限公司 2025-04-04 CN claimed
CN-118179544-B Preparation method of propane dehydrogenation catalyst 烟台百川汇通科技有限公司 2024-07-12 CN claimed
CN-118179544-A Preparation method of propane dehydrogenation catalyst 烟台百川汇通科技有限公司 2024-06-14 CN claimed
CN-114621191-B EZH2 inhibitor and preparation and application thereof 东南大学 2023-08-15 CN claimed
CN-114621191-A EZH2 inhibitor and preparation and application thereof 东南大学 2022-06-14 CN claimed
US-12630563-B2 Macrocyclic RIP2-kinase inhibitors ONCODESIGN S.A. (FR) 2026-05-19 US disclosed
US-20260125396-A1 MACROCYCLIC RIP2-KINASE INHIBITORS ONCODESIGN S.A. (FR) 2026-05-07 US disclosed
US-12435066-B2 Substituted tricyclic compounds LUPIN LIMITED (IN) 2025-10-07 US disclosed
CN-119751962-A Preparation method of heat radiation aerogel for lithium battery 广东宇阳新能源有限公司 2025-04-04 CN disclosed
CN-115698020-B Macrocyclic RIP 2-kinase inhibitors 昂科迪塞恩精密医药公司(OPM) 2025-02-25 CN disclosed
CN-119264055-A WDR5 inhibitor and preparation method and application thereof 中国科学院上海药物研究所 2025-01-07 CN disclosed
EP-4434522-A2 HETEROCYCLIC P2Y14 RECEPTOR ANTAGONISTS The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2024-09-25 EP disclosed
EP-2103618-A1 Novel ansamitocin derivatives Leibniz Universität Hannover (DE) 2009-09-23 EP disclosed
US-20070249591-A1 Biaryl Amino Acids and Their Use in Dna Binding Oligomers SPIROGEN LIMITED (GB) 2007-10-25 US disclosed
US-20070249591-A1 Biaryl Amino Acids and Their Use in Dna Binding Oligomers SPIROGEN LIMITED (GB) 2007-10-25 US disclosed
US-20070082912-A1 Pyrrole compounds for the treatment of prostaglandine mediated diseases GLAXO GROUP LIMITED (GB) 2007-04-12 US disclosed
EP-1509499-A1 PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES GLAXO GROUP LIMITED (GB) 2005-03-02 EP disclosed
WO-2003101959-A1 PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES GLAXO GROUP LIMITED (GB) 2003-12-11 WO disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249591-A1 Biaryl Amino Acids and Their Use in Dna Binding Oligomers PCNA, POLL, DNA2 KDM4E 3490/4885MEN1 3594/4885KMT2A 700/4885
US-20070082912-A1 Pyrrole compounds for the treatment of prostaglandine mediated diseases PTGER1, PTGDR, PTGIR KDM4E 1761/4885MEN1 1556/4885KMT2A 2989/4885
US-20260125396-A1 MACROCYCLIC RIP2-KINASE INHIBITORS RIPK1, RIPK2, RIPK4 KDM4E 4123/4885MEN1 1403/4885KMT2A 3726/4885
US-12630563-B2 Macrocyclic RIP2-kinase inhibitors RIPK1, RIPK2, RIPK3 KDM4E 3518/4885MEN1 3378/4885KMT2A 2994/4885
US-12435066-B2 Substituted tricyclic compounds SOS1, RSU1, KSR1 KDM4E 4652/4885MEN1 31/4885KMT2A 4241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.