SCHEMBL10286111

SCHEMBL10286111

C#CCOc1cc2c(nc1C)C(=O)CCCC2

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.33
MAOA P21397 5/20 0.33
KMT2A Q03164 3/20 0.32
PGK1 P00558 1/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10286208 0.83 KDM4E (0.37) MAOBMAOAKMT2AMEN1POLB
SCHEMBL10286115 0.79 ALDH1A1 (0.41) MAOAKMT2AMEN1
SCHEMBL10286100 0.76 L3MBTL1 (0.36) MAOBMAOAKMT2APGK1MEN1
SCHEMBL10286580 0.76 ALDH1A1 (0.44) MAOAKMT2AMEN1
SCHEMBL10286196 0.74 MAOB (0.32) MAOBMAOAPGK1
SCHEMBL10286493 0.74 L3MBTL1 (0.36) MAOBMAOAKMT2APGK1MEN1
SCHEMBL10286156 0.72 NPC1 (0.34) MAOBMAOAKMT2AMEN1
SCHEMBL10286109 0.71 HSD17B1 (0.34) MAOBMAOA
SCHEMBL10286474 0.69 KDM4E (0.33) MAOBMAOAKMT2AMEN1
SCHEMBL10286632 0.68 HSD17B1 (0.37) MAOBMAOAKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130102631-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2013-04-25 US disclosed
US-20130102631-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2013-04-25 US disclosed
WO-2012001040-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130102631-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES MSR1, DDT, MPO MAOB 473/4885MAOA 334/4885KMT2A 1808/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.