Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PYGL | P06737 | 1/20 | 0.53 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PPOX | P50336 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026951 | 0.86 | TDP1 (0.50) | KDM4EPYGLAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL27834942 | 0.85 | POLB (0.50) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6567226 | 0.85 | KDM4E (0.62) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL21612801 | 0.84 | MAPT (0.58) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2724028 | 0.83 | TDP1 (0.62) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL3889423 | 0.83 | MEN1 (0.55) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1353346 | 0.83 | VCAM1 (0.57) | AKR1C4AKR1C3AKR1C2AKR1C1HPGD | |
| SCHEMBL1026867 | 0.81 | TDP1 (0.55) | KDM4EPYGLAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL10784720 | 0.81 | TDP1 (0.70) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1075103 | 0.81 | MEN1 (0.51) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071197-A1 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | BIOLIPOX AB (LV) | 2011-03-24 | — | — | US | disclosed |
| EP-2274280-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | Biolipox AB (SE) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127822-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | BIOLIPOX AB (SE) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071197-A1 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | LTC4S, LTB4R2, LTB4R | KDM4E 3760/4885PYGL 1226/4885AKR1C4 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.