Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | PPOX | P50336 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 3/20 | 0.48 |
| ▸ | DTYMK | P23919 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30580504 | 0.90 | AKR1C3 (0.63) | KDM4EAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL269614 | 0.90 | AKR1C3 (0.63) | KDM4EAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL3889423 | 0.87 | MEN1 (0.55) | KDM4EPOLBAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL1075103 | 0.85 | MEN1 (0.51) | KDM4EPOLBAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL1028818 | 0.85 | KDM4E (0.54) | KDM4EPOLBAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL8630071 | 0.84 | PIN1 (0.46) | KDM4EPOLBAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL3892796 | 0.81 | TDP1 (0.50) | KDM4EPOLBAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL6565205 | 0.81 | MTNR1B (0.45) | KDM4EPOLBAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL6567283 | 0.81 | MEN1 (0.68) | KDM4EAKR1C3AKR1C2AKR1B1AKR1C4 | |
| SCHEMBL10976077 | 0.80 | MEN1 (0.61) | KDM4EPOLBAKR1C3AKR1C2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |