Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11466945 | 0.80 | LMNA (0.55) | LMNAALDH1A1TSHRBCL2MCL1 | |
| SCHEMBL28034398 | 0.80 | GABRA1 (0.42) | LMNAALDH1A1TSHRBCL2MCL1 | |
| SCHEMBL13900943 | 0.79 | TSHR (0.39) | LMNAALDH1A1TSHRGAAHIF1A | |
| SCHEMBL28116650 | 0.77 | BCL2 (0.56) | LMNAALDH1A1TSHRBCL2MCL1 | |
| SCHEMBL17304955 | 0.76 | TSHR (0.39) | LMNAALDH1A1TSHRGAAALOX5AP | |
| SCHEMBL12843999 | 0.76 | TSHR (0.39) | LMNAALDH1A1TSHRGAAALOX5AP | |
| SCHEMBL27501139 | 0.76 | KCNMA1 (0.53) | LMNAALDH1A1TSHRHTTHIF1A | |
| SCHEMBL29565 | 0.75 | CYP3A4 (0.51) | LMNAALDH1A1TSHRGAAHIF1A | |
| SCHEMBL21901400 | 0.74 | ESR1 (0.44) | LMNATSHRGAAHIF1ACACNA1B | |
| SCHEMBL9340821 | 0.74 | NPC1 (0.64) | LMNAALDH1A1TSHRHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265692-B1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | MERCK PATENT GMBH (DE) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011107218-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011009524-A1 | LIQUID CRYSTAL MEDIUM AND HIGH-FREQUENCY COMPONENTS CONTAINING THE SAME | MERCK PATENT GMBH (DE) | 2011-01-27 | — | — | WO | disclosed |
| EP-1832643-B1 | Liquid crystalline medium and liquid-crystal display | MERCK PATENT GMBH (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-1808473-B1 | Liquid crystal medium | MERCK PATENT GMBH (DE) | 2010-02-10 | — | — | EP | disclosed |
| EP-2085454-A1 | Liquid crystal medium and liquid crystal display | MERCK PATENT GmbH (DE) | 2009-08-05 | — | — | EP | disclosed |