SCHEMBL1029657

SCHEMBL1029657

COc1ccc(CNC(=O)Oc2c(-c3ccco3)c(C)cn2C)cc1OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
RECQL P46063 3/20 0.48
MAPT P10636 2/20 0.46
HTT P42858 2/20 0.46
LMNA P02545 2/20 0.46
ADORA3 P0DMS8 4/20 0.44
ADORA2A P29274 4/20 0.44
ADORA1 P30542 4/20 0.44
UBE2I P63279 1/20 0.44
CACNA1B Q00975 1/20 0.44
APBA1 Q02410 1/20 0.44
SAE1 Q9UBE0 1/20 0.44
UBA2 Q9UBT2 1/20 0.44
HSD17B10 Q99714 3/20 0.43
TP53 P04637 3/20 0.43
USP2 O75604 2/20 0.43
ALOX15 P16050 2/20 0.43
MAPK1 P28482 2/20 0.43
POLB P06746 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1032179 0.87 ADORA3 (0.49) ALDH1A1SMN1; SMN2RECQLHTTLMNA
SCHEMBL1032676 0.85 ADORA3 (0.49) ALDH1A1SMN1; SMN2RECQLMAPTHTT
SCHEMBL1032390 0.75 P2RX7 (0.42)
SCHEMBL1032207 0.73 ADORA3 (0.40) ALDH1A1SMN1; SMN2RECQLMAPTHTT
SCHEMBL1030275 0.73 L3MBTL1 (0.40) ALDH1A1RECQLMAPTHTTLMNA
SCHEMBL1032103 0.72 TAS1R3 (0.43) ALDH1A1UBE2ICACNA1BAPBA1SAE1
SCHEMBL1029462 0.71 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL1032230 0.71 ADORA3 (0.55) ALDH1A1SMN1; SMN2RECQLHTTLMNA
SCHEMBL1031252 0.71 TDP1 (0.44) ALDH1A1RECQLCACNA1BAPBA1HSD17B10
SCHEMBL1029337 0.69 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2RECQLMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035375-B1 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-01-19 EP claimed
EP-2035375-A1 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS Grünenthal GmbH (DE) 2009-03-18 EP claimed
WO-2007141039-A1 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-13 WO claimed
EP-2035375-B1 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-01-19 EP disclosed
EP-2035375-A1 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS Grünenthal GmbH (DE) 2009-03-18 EP disclosed
WO-2007141039-A1 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-13 WO disclosed