Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1099587 | 0.77 | ACLY (0.47) | PSIP1HPGDLMNAKDM4EGAA | |
| SCHEMBL23303025 | 0.72 | CNR2 (0.46) | GAAALDH1A1PADI4GPR3CYP2A6 | |
| SCHEMBL11888064 | 0.71 | HSD11B1 (0.38) | LMNAMAPTALDH1A1ABCC1ABCG2 | |
| SCHEMBL1160897 | 0.70 | HSD11B1 (0.36) | MAPTALDH1A1ABCC1ABCG2ACLY | |
| SCHEMBL1093585 | 0.70 | GPR3 (0.44) | HPGDLMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL2061089 | 0.68 | HSD11B1 (0.39) | LMNAMAPTALDH1A1ABCC1ABCG2 | |
| SCHEMBL2061560 | 0.68 | HSD11B1 (0.42) | LMNAGAAMAPTMEN1ALDH1A1 | |
| SCHEMBL19225704 | 0.68 | GPR3 (0.46) | HPGDLMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL843065 | 0.68 | GPR3 (0.46) | HPGDLMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL10280855 | 0.67 | HSD11B1 (0.50) | LMNAMAPTABCC1ABCG2ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8216547-B2 | Radiolabelled TRP M8 receptor ligands | JANSSEN PHARMACEUTICA NV (BE) | 2012-07-10 | — | — | US | disclosed |
| US-8216547-B2 | Radiolabelled TRP M8 receptor ligands | JANSSEN PHARMACEUTICA NV (BE) | 2012-07-10 | — | — | US | disclosed |
| US-20100015053-A1 | RADIOLABELLED TRP M8 RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-21 | — | — | US | disclosed |
| US-20100015053-A1 | RADIOLABELLED TRP M8 RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-21 | — | — | US | disclosed |
| WO-2010009220-A2 | RADIOLABELLED TRP M8 RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100015053-A1 | RADIOLABELLED TRP M8 RECEPTOR LIGANDS | TRPM8, TRPM7, GPR68 | PSIP1 3684/4885HPGD 4048/4885LMNA 3395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.