Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10301552 | 0.87 | CYP3A4 (0.39) | KDM4EGAAKMT2ACYP3A4CYP2D6 | |
| SCHEMBL2278242 | 0.82 | CES2 (0.62) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL10475039 | 0.80 | MKNK1 (0.44) | KMT2AMEN1CYP3A4TDP1 | |
| SCHEMBL1374066 | 0.80 | ALDH1A1 (0.64) | KMT2AMAPK1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL29153391 | 0.80 | KDM4E (0.61) | KDM4EGAAKMT2AMEN1CYP3A4 | |
| SCHEMBL10480836 | 0.79 | KDM4E (0.56) | KDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL9839394 | 0.78 | SMN1; SMN2 (0.50) | KDM4EGAACYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL22498722 | 0.77 | CYP3A4 (0.56) | KMT2ACYP3A4CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL27238307 | 0.77 | GAA (0.49) | KDM4EGAAKMT2AMEN1CYP3A4 | |
| SCHEMBL11247310 | 0.77 | ALDH1A1 (0.65) | KDM4EKMT2AMEN1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156772-B2 | Fluoride-releasing compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-13 | — | — | US | disclosed |
| US-20140088308-A1 | Fluoride-Releasing Compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-03-27 | — | — | US | disclosed |
| US-20120264939-A1 | Fluoride-Releasing Compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-10-18 | — | — | US | disclosed |
| US-8217173-B2 | Fluoride-releasing compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2012-07-10 | — | — | US | disclosed |
| US-20100261902-A1 | Fluoride-Releasing Compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088308-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | KDM4E 3444/4885GAA 435/4885KMT2A 3397/4885 |
| US-20120264939-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | KDM4E 3444/4885GAA 435/4885KMT2A 3397/4885 |
| US-20100261902-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | KDM4E 3444/4885GAA 435/4885KMT2A 3397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.