Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.55 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARD | Q03181 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665865 | 0.93 | GSTK1 (0.46) | FOLH1GSTK1ENPEPFFAR4FFAR1 | |
| SCHEMBL10307794 | 0.86 | ALDH1A1 (0.53) | GSTK1FFAR4FFAR1ALDH1A1AKR1B1 | |
| SCHEMBL15833790 | 0.84 | FFAR4 (0.62) | FFAR4FFAR1ALDH1A1AKR1B1TSHR | |
| SCHEMBL3113224 | 0.81 | TSHR (0.56) | FFAR4FFAR1ALDH1A1AKR1B1TSHR | |
| SCHEMBL11514264 | 0.78 | FFAR4 (0.73) | FFAR4FFAR1ALDH1A1TSHRKMT2A | |
| SCHEMBL10307776 | 0.77 | GSTK1 (0.52) | FOLH1GSTK1ENPEPFFAR4FFAR1 | |
| SCHEMBL15468633 | 0.76 | GSTK1 (0.32) | GSTK1 | |
| SCHEMBL17255853 | 0.75 | FFAR4 (0.51) | FFAR4FFAR1ALDH1A1AKR1B1TSHR | |
| SCHEMBL10307750 | 0.75 | GSTK1 (0.48) | FOLH1GSTK1ENPEPFFAR4FFAR1 | |
| SCHEMBL13739049 | 0.74 | FOLH1 (0.64) | FOLH1GSTK1ENPEPFFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263653-B2 | Pharmaceutical formulations containing lipoic acid derivatives | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| US-20120178812-A1 | Pharmaceutical Formulations Containing Lipoic Acid Derivatives | RAFAEL PHARMACEUTICALS, INC. | 2012-07-12 | — | — | US | disclosed |
| WO-2011050261-A1 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
| US-20100190858-A1 | Pharmaceutical Formulations Containing Lipoic Acid Derivatives | RAFAEL PHARMACEUTICALS, INC. | 2010-07-29 | — | — | US | disclosed |
| WO-2008131114-A2 | PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080262077-A1 | formulations containing lipoic acid derivatives are made. | CORNERSTONE PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190858-A1 | Pharmaceutical Formulations Containing Lipoic Acid Derivatives | SLC25A1, SLC25A21, SLC25A11 | FOLH1 1346/4885GSTK1 2881/4885ENPEP 2852/4885 |
| US-20120178812-A1 | Pharmaceutical Formulations Containing Lipoic Acid Derivatives | LIPA, LIPC, TTPA | FOLH1 1432/4885GSTK1 2372/4885ENPEP 2178/4885 |
| US-20080262077-A1 | formulations containing lipoic acid derivatives are made. | TTPA, LIPA, LIPC | FOLH1 1694/4885GSTK1 1821/4885ENPEP 2402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.