Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDYL2 | Q8N8U2 | 7/20 | 0.52 |
| ▸ | CDYL | Q9Y232 | 6/20 | 0.52 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 6/20 | 0.52 |
| ▸ | CBX7 | O95931 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063569 | 0.86 | CDYL2 (0.48) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL17677357 | 0.76 | MAPT (0.49) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL12963052 | 0.74 | SMN1; SMN2 (0.45) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL1058048 | 0.74 | SMN1; SMN2 (0.47) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL10314590 | 0.74 | SMN1; SMN2 (0.48) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL14780911 | 0.73 | CA12 (0.42) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL1062513 | 0.72 | KMT2A (0.51) | SMN1; SMN2NPC1MAPTRAB9AKDM4E | |
| SCHEMBL12963043 | 0.71 | LMNA (0.43) | NPC1MAPTRAB9APOLBCA12 | |
| SCHEMBL15030495 | 0.69 | CDYL2 (0.54) | CDYL2CDYLCDY1; CDY1BCBX7SMN1; SMN2 | |
| SCHEMBL733307 | 0.69 | CES2 (0.67) | SMN1; SMN2NPC1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217176-B2 | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20110003788-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20090227561-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003788-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | SMO, NR1H2, NR1H4 | CDYL2 1661/4885CDYL 1321/4885CDY1; CDY1B 1350/4885 |
| US-20090227561-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | SMO, NR1H2, NR1H4 | CDYL2 1550/4885CDYL 1296/4885CDY1; CDY1B 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.