Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 5/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.31 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772465 | 0.84 | AKR1C3 (0.37) | SLC6A2P2RY14TOP2AKIF11MEN1 | |
| SCHEMBL6113613 | 0.84 | PTGS2 (0.33) | PTGS2 | |
| SCHEMBL16713281 | 0.84 | SLC6A2 (0.44) | SLC6A2P2RY14PTGS2MAPK1MAP2K4 | |
| SCHEMBL1963833 | 0.83 | ALDH1A1 (0.34) | SLC6A2P2RY14TDP2KMT2AIL1B | |
| SCHEMBL30104207 | 0.83 | ALDH1A1 (0.34) | SLC6A2P2RY14TDP2KMT2AIL1B | |
| SCHEMBL6113895 | 0.81 | PDK2 (0.43) | KIF11 | |
| SCHEMBL9934917 | 0.80 | PDK2 (0.35) | SLC6A2P2RY14TOP2AKIF11PTGS2 | |
| SCHEMBL20779077 | 0.78 | PARP1 (0.40) | KIF11TDP2MAPK1 | |
| SCHEMBL1815597 | 0.78 | KCNH2 (0.36) | MEN1KMT2ACYP2C9ALOX5APFEN1 | |
| SCHEMBL16742523 | 0.76 | PDK2 (0.41) | SLC6A2P2RY14KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2652551-B1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | TRANSITIONS OPTICAL INC (US) | 2015-12-30 | — | — | EP | disclosed |
| US-8859097-B2 | Photochromic compounds, compositions and articles | TRANSITIONS OPTICAL, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120183810-A1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183810-A1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | CRY2, H1-0, CRY1 | SLC6A2 1939/4885P2RY14 639/4885TOP2A 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.