Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | EPM2A | O95278 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30104207 | 1.00 | ALDH1A1 (0.34) | ALDH1A1KMT2ASMN1; SMN2CCNB2CDK1 | |
| SCHEMBL29664007 | 0.83 | CSNK2A2 (0.34) | KMT2APDK2ALKPIM1BIRC5 | |
| SCHEMBL1962962 | 0.83 | CSNK2A2 (0.34) | KMT2APDK2ALKPIM1BIRC5 | |
| SCHEMBL30658606 | 0.83 | TDP2 (0.31) | KMT2ATDP2TMPRSS4 | |
| SCHEMBL9933671 | 0.83 | TDP2 (0.31) | KMT2ATDP2TMPRSS4 | |
| SCHEMBL10323482 | 0.83 | SLC6A2 (0.35) | KMT2ATDP2SLC6A2P2RY14IL1B | |
| SCHEMBL1815597 | 0.80 | KCNH2 (0.36) | KMT2ACCNB2CDK1CCNB1GSK3B | |
| SCHEMBL23572603 | 0.80 | PPM1A (0.37) | ALDH1A1KMT2AALK | |
| SCHEMBL30104206 | 0.80 | PPM1A (0.37) | ALDH1A1KMT2AALK | |
| SCHEMBL23572608 | 0.79 | MAPT (0.36) | ALDH1A1KMT2ASMN1; SMN2PDK2TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518751-B2 | Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence | TRANSITIONS OPTICAL, LTD. (IE) | 2022-12-06 | — | — | US | disclosed |
| EP-3802508-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRAN COMPOUNDS WITH REDUCED TEMPERATURE DEPENDENCE | TRANSITIONS OPTICAL LTD (IE) | 2022-10-19 | — | — | EP | disclosed |
| US-20210198226-A1 | Photochromic Indeno-Fused Naphthopyran Compounds With Reduced Temperature Dependence | TRANSITIONS OPTICAL, LTD. (IE) | 2021-07-01 | — | — | US | disclosed |
| EP-3045971-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | Transitions Optical, Inc. (US) | 2016-07-20 | — | — | EP | disclosed |
| EP-2652553-B1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL INC (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-2652553-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | Transitions Optical, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| US-8518546-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2012082383-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20110143141-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110143141-A1 | Photochromic compounds and compositions | CCNA1, CRY1, CCNT1 | ALDH1A1 43/4885KMT2A 563/4885SMN1; SMN2 3964/4885 |
| US-20210198226-A1 | Photochromic Indeno-Fused Naphthopyran Compounds With Reduced Temperature Dependence | NR2E3, NR0B2, NR2C2 | ALDH1A1 1149/4885KMT2A 1967/4885SMN1; SMN2 1569/4885 |
| US-11518751-B2 | Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence | NR2E3, NR0B2, NR2C2 | ALDH1A1 1149/4885KMT2A 1967/4885SMN1; SMN2 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.