Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031848 | 0.85 | RAB9A (0.53) | RAB9ANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1027589 | 0.79 | MAPT (0.41) | ALDH1A1KMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL2637921 | 0.78 | MAPT (0.48) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1031786 | 0.77 | PPARG (0.47) | RAB9AALDH1A1HPGDPKMMAPT | |
| SCHEMBL1029107 | 0.77 | KDM4E (0.49) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL1028192 | 0.73 | HIF1A (0.47) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1028662 | 0.73 | LMNA (0.48) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL4103785 | 0.72 | MAPT (0.45) | RAB9ANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1033737 | 0.71 | NPC1 (0.49) | RAB9ANPC1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1031268 | 0.69 | ALDH1A1 (0.39) | NPC1ALDH1A1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |