Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031613 | 0.74 | ALDH1A1 (0.61) | HPGDSMN1; SMN2POLBCNR1ALDH1A1 | |
| SCHEMBL1031909 | 0.74 | NPC1 (0.47) | NPC1RAB9AHPGDSMN1; SMN2MTNR1A | |
| SCHEMBL1030212 | 0.74 | NPC1 (0.61) | NPC1RAB9APOLBPTGS2TSHR | |
| SCHEMBL1031848 | 0.74 | RAB9A (0.53) | NPC1RAB9AHPGDSMN1; SMN2POLB | |
| SCHEMBL2637715 | 0.73 | GRIA2 (0.45) | NPC1RAB9AHPGDSMN1; SMN2POLB | |
| SCHEMBL1032252 | 0.72 | HTT (0.46) | HPGDSMN1; SMN2ALDH1A1CA1CA2 | |
| SCHEMBL1030747 | 0.72 | NPC1 (0.53) | NPC1RAB9AHPGDSMN1; SMN2MAPT | |
| SCHEMBL24272429 | 0.72 | NPC1 (0.71) | NPC1RAB9AHPGDSMN1; SMN2POLB | |
| SCHEMBL1032473 | 0.71 | RAB9A (0.48) | NPC1RAB9AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL1031541 | 0.71 | RAB9A (0.53) | NPC1RAB9AHPGDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |