Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62789 | 0.92 | — | — | |
| SCHEMBL23045151 | 0.89 | — | — | |
| SCHEMBL8521229 | 0.89 | GAA (0.42) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL13734952 | 0.86 | MEN1 (0.58) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL14266911 | 0.86 | MEN1 (0.56) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL15803251 | 0.86 | MEN1 (0.58) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL28482200 | 0.86 | GAA (0.45) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL2428341 | 0.86 | MEN1 (0.56) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL9951247 | 0.86 | MEN1 (0.56) | MEN1KMT2ATHRBHTTMAPT | |
| SCHEMBL6662250 | 0.85 | HDAC3 (0.40) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9308274-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140256951-A1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2014-09-11 | — | — | US | disclosed |
| US-8765883-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2014-07-01 | — | — | US | disclosed |
| US-20130280206-A1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS | 2013-10-24 | — | — | US | disclosed |
| US-8492488-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2013-07-23 | — | — | US | disclosed |
| US-20120258985-A1 | STABILIZED POLYMERIC THIOL REAGENTS | NEKTAR THERAPEUTICS (US) | 2012-10-11 | — | — | US | disclosed |
| US-8217123-B2 | Stabilized polymeric thiol reagents | NEKTAR THERAPEUTICS (US) | 2012-07-10 | — | — | US | disclosed |
| US-20110112277-A1 | Stabilized Polymeric Thiol Reagents | NEKTAR THERAPEUTICS (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130280206-A1 | STABILIZED POLYMERIC THIOL REAGENTS | TST, STS, SCLY | MEN1 4852/4885KMT2A 2667/4885THRB 3801/4885 |
| US-20110112277-A1 | Stabilized Polymeric Thiol Reagents | TST, CD44, MPST | MEN1 4757/4885KMT2A 3133/4885THRB 2935/4885 |
| US-20140256951-A1 | STABILIZED POLYMERIC THIOL REAGENTS | TST, TTPA, MPST | MEN1 4820/4885KMT2A 3099/4885THRB 4011/4885 |
| US-20120258985-A1 | STABILIZED POLYMERIC THIOL REAGENTS | TST, STS, CD44 | MEN1 4849/4885KMT2A 2736/4885THRB 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.