Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966091 | 0.88 | KMT2A (0.48) | LMNAFAAHTRPV1SMN1; SMN2TP53 | |
| SCHEMBL10327490 | 0.81 | ALDH1A1 (0.53) | LMNASMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL10327151 | 0.80 | LMNA (0.45) | LMNAFAAHTRPV1SMN1; SMN2TP53 | |
| SCHEMBL10327338 | 0.80 | ALDH1A1 (0.43) | LMNASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL10327506 | 0.80 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL10327476 | 0.79 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL10327240 | 0.74 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL10327382 | 0.74 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL10327385 | 0.74 | LMNA (0.46) | LMNAKMT2A | |
| SCHEMBL964852 | 0.73 | SMN1; SMN2 (0.47) | LMNAFAAHTRPV1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |