Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963935 | 0.88 | KMT2A (0.55) | LMNAMAPTKMT2ATP53MEN1 | |
| SCHEMBL10327149 | 0.82 | LMNA (0.53) | LMNAMAPTKMT2ATP53MEN1 | |
| SCHEMBL10327506 | 0.80 | SMN1; SMN2 (0.47) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL10327048 | 0.80 | SMN1; SMN2 (0.55) | LMNAMAPTKMT2ATP53MEN1 | |
| SCHEMBL10327331 | 0.79 | SMN1; SMN2 (0.51) | LMNAMAPTKMT2ATP53MEN1 | |
| SCHEMBL10327463 | 0.76 | LMNA (0.46) | LMNAMAPTKMT2ATP53MEN1 | |
| SCHEMBL10327490 | 0.75 | ALDH1A1 (0.53) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL10327465 | 0.75 | TRPV4 (0.40) | LMNAMAPTKMT2ATP53MEN1 | |
| SCHEMBL966073 | 0.75 | SMN1; SMN2 (0.46) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL963343 | 0.75 | KMT2A (0.50) | LMNAMAPTKMT2ATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |