Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031603 | 0.87 | CNR2 (0.47) | MAPTSMN1; SMN2TP53POLBCNR2 | |
| SCHEMBL1029484 | 0.86 | HSD11B1 (0.47) | ALDH1A1 | |
| SCHEMBL1028175 | 0.82 | TP53 (0.52) | MAPTSMN1; SMN2TP53POLBCNR2 | |
| SCHEMBL1030828 | 0.81 | MAPT (0.47) | MAPTSMN1; SMN2POLBGAAMAPK1 | |
| SCHEMBL1032620 | 0.80 | HTT (0.53) | MAPTSMN1; SMN2TP53POLBCNR2 | |
| SCHEMBL1031902 | 0.79 | LMNA (0.45) | MAPTSMN1; SMN2TP53POLBHTT | |
| SCHEMBL1031510 | 0.79 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL1030438 | 0.77 | MEN1 (0.61) | MAPTSMN1; SMN2POLBHTTLMNA | |
| SCHEMBL1031811 | 0.76 | HPGD (0.54) | MAPTSMN1; SMN2TP53POLBCNR2 | |
| SCHEMBL1031573 | 0.73 | KMT2A (0.52) | MAPTTP53LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |