SCHEMBL10338581

SCHEMBL10338581

CN1C(=O)C(Sc2ccccc2)C(c2ccccc2)C1=O

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.41
TSHR P16473 2/20 0.41
LMNA P02545 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
CARM1 Q86X55 1/20 0.35
PRMT6 Q96LA8 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
BRD4 O60885 3/20 0.34
MEN1 O00255 3/20 0.34
MAPT P10636 2/20 0.34
MAPK1 P28482 1/20 0.34
F2 P00734 2/20 0.33
PRSS1 P07477 2/20 0.33
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
ALDH1A1 P00352 1/20 0.33
POLB P06746 1/20 0.33
HPGD P15428 1/20 0.33
SRD5A1 P18405 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6294238 0.69 MAPT (0.38) KMT2ATSHRCARM1PRMT6MEN1
SCHEMBL10338582 0.69 TSHR (0.44) KMT2ATSHRLMNAADORA3SMN1; SMN2
SCHEMBL10407251 0.68 CRBN (0.44) KMT2ASMN1; SMN2MEN1MAPTF2
SCHEMBL14609274 0.67 ALDH1A1 (0.35) KMT2ATSHRLMNAADORA3SMN1; SMN2
SCHEMBL14543858 0.67 ALDH1A1 (0.35) KMT2ATSHRLMNAADORA3SMN1; SMN2
SCHEMBL6951037 0.64 KMT2A (0.46) KMT2ALMNASMN1; SMN2MEN1MAPT
SCHEMBL77736 0.63 LMNA (0.61) KMT2ATSHRLMNAADORA3SMN1; SMN2
SCHEMBL64294 0.62 KMT2A (0.48) KMT2ATSHRLMNABRD4MEN1
SCHEMBL14159333 0.62 CRBN (0.45) KMT2ALMNAADORA3SMN1; SMN2MEN1
SCHEMBL14574448 0.62 CRBN (0.45) KMT2ALMNAADORA3SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2085203-A None JP disclosed
JP-H0285203-A FUNGICIDE FOR LATE BLIGHT OR BROWN RUST OF PLANT FUJISAWA PHARMACEUT CO LTD 1990-03-26 JP disclosed