Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | CFD | P00746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176882 | 0.76 | KMT2A (0.52) | KDM4ERECQLKMT2AMEN1CFD | |
| SCHEMBL5696465 | 0.76 | LMNA (0.60) | KDM4ERECQLKMT2AMEN1CFD | |
| SCHEMBL3387199 | 0.75 | KMT2A (0.57) | KDM4ERECQLKMT2AMEN1ALDH1A1 | |
| SCHEMBL28617495 | 0.75 | KDM4E (0.48) | KDM4ERECQLKMT2AMEN1CFD | |
| SCHEMBL4749159 | 0.74 | DHODH (0.69) | KDM4EKMT2AMEN1CFDNPC1 | |
| SCHEMBL29367186 | 0.74 | TGM2 (0.58) | KDM4ERECQLKMT2AMEN1CFD | |
| SCHEMBL890714 | 0.74 | TGM2 (0.58) | KDM4ERECQLKMT2AMEN1CFD | |
| SCHEMBL14856040 | 0.74 | KMT2A (0.54) | KDM4ERECQLKMT2AMEN1NPC1 | |
| SCHEMBL140910 | 0.72 | KMT2A (0.54) | KDM4EKMT2AMEN1CFDPKM | |
| SCHEMBL8814 | 0.72 | CFD (0.53) | KDM4ERECQLKMT2AMEN1CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169537-B1 | 2-PHENYLALKYL-3-AMINOALKYL-4(3H)-QUINAZOLINONES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS AND USE | MITSUBISHI KASEI CORPORATION (JP) | 1990-01-03 | — | — | EP | disclosed |
| US-4668682-A | CALCIUM ANTAGONISTS, VASODILATORS, HYPOTENSIVE AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0169537-A2 | 2-Phenylalkyl-3-aminoalkyl-4(3H)-quinazolinones, processes for preparing them, pharmaceutical compositions and use | MITSUBISHI KASEI CORPORATION (JP) | 1986-01-29 | — | — | EP | disclosed |