Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29244184 | 0.98 | ALDH1A1 (0.44) | HRH4ALDH1A1TDP1CYP1A2HRH2 | |
| SCHEMBL10855415 | 0.85 | PRMT3 (0.39) | HRH4ALDH1A1TDP1CYP1A2HRH2 | |
| SCHEMBL17181018 | 0.78 | PAOX (0.43) | HRH4ALDH1A1TDP1CYP1A2HRH2 | |
| SCHEMBL9813294 | 0.78 | TDP1 (0.42) | HRH4ALDH1A1TDP1CYP1A2HRH2 | |
| SCHEMBL1176631 | 0.77 | ALDH1A1 (0.47) | HRH4ALDH1A1TDP1CYP1A2HRH2 | |
| Hydrochloric Acid SCHEMBL538616 | 0.75 | ALDH1A1 (0.47) | HRH4ALDH1A1TDP1CYP1A2HRH2 | |
| SCHEMBL23996073 | 0.74 | HDAC11 (0.31) | HSD17B10 | |
| SCHEMBL3166180 | 0.74 | — | — | |
| Iodide SCHEMBL28722729 | 0.72 | SPHK2 (0.38) | — | |
| SCHEMBL7864541 | 0.72 | PAOX (0.46) | ALDH1A1TDP1CYP2C9CYP2C19PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355279-A2 | Use of nitrogen-containing compounds as antiparasitics, and compositions containing them | DRUG & VACCINE DEVELOPMENT CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |