Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GAPDH | P04406 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27878861 | 0.86 | ALOX5 (0.41) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9215274 | 0.85 | ALOX5 (0.44) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2880798 | 0.81 | ALOX5 (0.39) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13988109 | 0.79 | CES2 (0.47) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9130249 | 0.78 | ALOX5 (0.39) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13026686 | 0.77 | ALOX5 (0.42) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7607466 | 0.77 | ALOX5 (0.42) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27891940 | 0.77 | CES2 (0.46) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28059872 | 0.76 | CYP2C19 (0.40) | ALOX5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17787300 | 0.75 | ALOX5 (0.37) | ALOX5RAB9ANPC1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221806-B1 | SUBSTITUTED THIOPHENE-2-SULFANOMIDE AND ANTIGLAUCOMA COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0221806-A1 | Substituted thiophene-2-sulfanomide and antiglaucoma compositions containing them | MERCK & CO. INC. (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4665090-A | TOPICAL ADMINISTRATION | MERCK & CO., INC. (US) | 1987-05-12 | — | — | US | disclosed |