Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13988109 | 0.80 | CES2 (0.47) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL27891940 | 0.79 | CES2 (0.46) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL13026686 | 0.79 | ALOX5 (0.42) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL10340979 | 0.77 | ALOX5 (0.41) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL9215274 | 0.76 | ALOX5 (0.44) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL27482821 | 0.76 | POLB (0.45) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL4574168 | 0.76 | ALOX5 (0.46) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL6129396 | 0.75 | — | — | |
| SCHEMBL28095673 | 0.75 | ALOX5 (0.40) | ALOX5ALDH1A1RAB9ANPC1CES2 | |
| SCHEMBL27347277 | 0.73 | ALOX5 (0.47) | ALOX5ALDH1A1RAB9ANPC1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263714-A1 | NOVEL PHENYLHETEROALKYLAMINE DERIVATIVES | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062713-A1 | NOVEL PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |
| EP-1059922-A2 | GLYCINE TRANSPORT INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044596-A2 | GLYCINE TRANSPORT INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-09-10 | — | — | WO | disclosed |
| EP-0707584-A1 | NOVEL (1-HETEROAZOLYL-1-HETEROCYCLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| US-5446060-A | Aminoalkyl thienyl ketone derivatives and their use as peripheral vasodilators | LABORATOIRE L. LAFON (FR) | 1995-08-29 | — | — | US | disclosed |
| EP-0025288-A1 | Derivatives of monic acid, processes for their preparation, compositions containing them and their preparation | BEECHAM GROUP PLC (GB) | 1981-03-18 | — | — | EP | disclosed |