Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.46 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.46 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10341371 | 1.00 | MAPT (0.47) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL11205822 | 0.80 | AKR1C3 (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8354130 | 0.79 | LMNA (0.54) | MAPTRAB9AMEN1KMT2ALMNA | |
| SCHEMBL11409731 | 0.78 | ALOX5 (0.52) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8354821 | 0.74 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL13879185 | 0.74 | ALOX5 (0.48) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2739302 | 0.74 | ALOX5 (0.48) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8354825 | 0.74 | AKR1C3 (0.51) | MAPTRAB9AMEN1KMT2ALMNA | |
| SCHEMBL9815440 | 0.73 | LMNA (0.53) | MAPTRAB9AMEN1KMT2ALMNA | |
| SCHEMBL9815439 | 0.73 | LMNA (0.53) | MAPTRAB9AMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0195582-B1 | 5-AMINOSALICYLIC ACID DERIVATIVES OF NON-STEROIDAL ANTIINFLAMMATORY ACIDS | SMITH KLINE DAUELSBERG GmbH (DE) | 1990-01-24 | — | — | EP | disclosed |
| US-4851443-A | NON-STEROIDAL ANTIINFLAMMATORY; DERIVATIVES OF 5-AMINOSALICYLIC ACID | SMITH KLINE DAUELSBERG, GMBH (DE) | 1989-07-25 | — | — | US | disclosed |
| US-4783487-A | N-(1-carboxy-2-hydroxy-5-phenyl)-2-(6-methoxy-2-naphthyl)propionamide and anti-inflammatory use thereof | SMITH KLINE DAUELSBERG GMBH (DE) | 1988-11-08 | — | — | US | disclosed |