Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354825 | 0.92 | AKR1C3 (0.51) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL4663300 | 0.87 | AKR1C3 (0.62) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL5554558 | 0.84 | AKR1C3 (0.47) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL4377895 | 0.84 | AKR1C3 (0.57) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL8360216 | 0.81 | CNR2 (0.46) | PTGS2AKR1C3AKR1C2CNR2AKR1C4 | |
| SCHEMBL10341372 | 0.79 | MAPT (0.47) | LMNACYP2C9NFKB1MEN1ALOX5 | |
| SCHEMBL8354821 | 0.79 | RAB9A (0.47) | PLA2G2AMEN1ALOX5RAB9AKMT2A | |
| SCHEMBL10341371 | 0.79 | MAPT (0.47) | LMNACYP2C9NFKB1MEN1ALOX5 | |
| SCHEMBL6025667 | 0.77 | LMNA (0.62) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL2073237 | 0.73 | AKR1B1 (0.46) | PLA2G2AKDM4EAKR1B1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |
| US-4711879-A | IMMUNO-MODULATING ACTIVITY | CIBA-GEIGY CORPORATION (US) | 1987-12-08 | — | — | US | disclosed |
| US-4640911-A | IMMUNOSTIMULANTS, VIRICIDES SUCH AS HERPES SIMPLEX | CIBA-GEIGY CORPORATION (US) | 1987-02-03 | — | — | US | disclosed |
| EP-0163286-A2 | Acylated sugars, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |