Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9815439 | 1.00 | LMNA (0.53) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| Cinmetacin SCHEMBL29974302 | 0.89 | LMNA (0.68) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| Cinmetacin SCHEMBL25138 | 0.89 | LMNA (0.68) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| Cinmetacin SCHEMBL25139 | 0.89 | LMNA (0.68) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL13229808 | 0.88 | LMNA (0.53) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL12609001 | 0.88 | LMNA (0.58) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| Cinmetacin SCHEMBL8636225 | 0.88 | LMNA (0.67) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| Cinmetacin SCHEMBL8636226 | 0.88 | LMNA (0.67) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL12628642 | 0.88 | AKR1C3 (0.62) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL3459041 | 0.88 | PLA2G2A (0.69) | LMNACYP1A2CYP2D6CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452908-A2 | Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids | ABBOTT LABORATORIES (US) | 1991-10-23 | — | — | EP | disclosed |