Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6441679 | 0.81 | LMNA (0.43) | SCN9AACHEKCNQ2OPRM1OPRD1 | |
| Bromide SCHEMBL11466962 | 0.79 | SMN1; SMN2 (0.30) | SCN9AKDM4E | |
| Phosphoric Acid SCHEMBL10790954 | 0.76 | TSHR (0.39) | SCN9AACHEKCNQ2OPRM1OPRD1 | |
| SCHEMBL10790946 | 0.70 | SRC (0.36) | SCN9AACHEKCNQ2OPRM1OPRD1 | |
| SCHEMBL618870 | 0.67 | OPRM1 (0.48) | OPRM1LMNATSHR | |
| SCHEMBL2096904 | 0.67 | DRD1 (0.48) | ACHE | |
| SCHEMBL17602223 | 0.67 | DRD1 (0.48) | ACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL17276390 | 0.67 | ACHE (0.46) | ACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL7620197 | 0.67 | DRD1 (0.45) | LMNATSHRNPSR1KDM4E | |
| Bromide SCHEMBL11460380 | 0.67 | POLB (0.35) | LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230755-B1 | 1-PHENYL-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0230755-A1 | 1-Phenyl-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-05 | — | — | EP | disclosed |