Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345275 | 0.76 | SLC6A2 (0.40) | L3MBTL1GLAKDM4ESLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL10345210 | 0.75 | SLC6A2 (0.39) | L3MBTL1GLAKDM4ESLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL10345700 | 0.70 | GLA (0.41) | L3MBTL1GLAKDM4EOPRM1MRGPRX4 | |
| SCHEMBL10345284 | 0.69 | PIM1 (0.41) | L3MBTL1GLAKDM4ESLC6A2SLC6A4 | |
| SCHEMBL13794516 | 0.67 | L3MBTL1 (0.67) | L3MBTL1GLAKDM4EMRGPRX4CYP2D6 | |
| SCHEMBL10345233 | 0.65 | SLC6A2 (0.41) | L3MBTL1GLAOPRM1SLC6A2SLC6A4 | |
| SCHEMBL27935397 | 0.65 | HTR1A (0.39) | L3MBTL1KDM4ESLC6A2SLC6A4ALDH1A1 | |
| 1,2-Diethoxybenzene SCHEMBL28398613 | 0.62 | L3MBTL1 (0.74) | L3MBTL1GLAMRGPRX4ALDH1A1MAPT | |
| SCHEMBL10345634 | 0.62 | SIGMAR1 (0.45) | L3MBTL1GLAOPRM1SLC6A2SLC6A4 | |
| SCHEMBL24944661 | 0.61 | OPRM1 (0.48) | L3MBTL1GLAKDM4EOPRM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152236-B1 | ARYLOXYMETHYLPYRROLIDINOLS AND PIPERIDINOLS HAVING ANTIDEPRESSANT, ANTIARHYTHMIC OR HYPOTENSIVE ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-04-18 | — | — | EP | disclosed |