Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 10/20 | 0.41 |
| ▸ | DRD3 | P35462 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.41 |
| ▸ | HTR1D | P28221 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | HTR1E | P28566 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.41 |
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10347509 | 0.80 | HTR1A (0.41) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| SCHEMBL10347239 | 0.80 | DRD2 (0.53) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| Bromide SCHEMBL10347450 | 0.79 | DRD2 (0.52) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL10870298 | 0.75 | DRD2 (0.48) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| SCHEMBL10920726 | 0.71 | DRD2 (0.70) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| Bromide SCHEMBL10919553 | 0.70 | DRD2 (0.68) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| SCHEMBL10833956 | 0.69 | OPRK1 (0.41) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| SCHEMBL11304680 | 0.69 | HTR1A (0.59) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| SCHEMBL9687997 | 0.68 | OPRK1 (0.45) | OPRK1DRD3HTR1AADRA2AADRA2B | |
| SCHEMBL11304682 | 0.62 | OPRK1 (0.71) | OPRK1DRD3HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175525-B1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0175525-B1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0175525-A1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4554287-A | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BECKMAN CORPORATION (US) | 1985-11-19 | — | — | US | disclosed |
| US-4554287-A | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BECKMAN CORPORATION (US) | 1985-11-19 | — | — | US | disclosed |