Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 5/20 | 0.53 |
| ▸ | DRD1 | P21728 | 4/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | DRD5 | P21918 | 4/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10347450 | 0.99 | DRD2 (0.52) | DRD2DRD3DRD1DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL10870298 | 0.93 | DRD2 (0.48) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL10347485 | 0.91 | DRD2 (0.48) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL10347652 | 0.80 | SIGMAR1 (0.39) | — | |
| SCHEMBL10347292 | 0.80 | OPRK1 (0.41) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL9688810 | 0.71 | DRD2 (0.53) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL10957766 | 0.70 | HTR1A (0.57) | DRD2DRD3DRD1DRD4DRD5 | |
| Skf-89124A SCHEMBL2914813 | 0.70 | DRD2 (1.00) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL10960456 | 0.69 | HTR1A (0.56) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL22705603 | 0.69 | HTR1A (0.56) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175525-B1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-23 | — | — | EP | claimed |
| EP-0175525-A1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1986-03-26 | — | — | EP | claimed |
| US-4554287-A | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BECKMAN CORPORATION (US) | 1985-11-19 | — | — | US | claimed |
| EP-0175525-B1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0175525-A1 | 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BEECHAM CORPORATION (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4554287-A | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones | SMITHKLINE BECKMAN CORPORATION (US) | 1985-11-19 | — | — | US | disclosed |