Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 10/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.45 |
| ▸ | HTR1D | P28221 | 6/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | HTR1E | P28566 | 6/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.45 |
| ▸ | HRH1 | P35367 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | HTR2B | P41595 | 6/20 | 0.45 |
| ▸ | HTR6 | P50406 | 6/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688738 | 0.79 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR1D | |
| SCHEMBL10410576 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL10821263 | 0.70 | HSP90AA1 (0.38) | LMNAHTTMAPT | |
| SCHEMBL10347292 | 0.68 | OPRK1 (0.41) | OPRK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11304680 | 0.67 | HTR1A (0.59) | OPRK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL28176890 | 0.67 | METAP2 (0.36) | MAPT | |
| SCHEMBL9688953 | 0.67 | AKR1B1 (0.42) | ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL9688897 | 0.65 | MPO (0.54) | DRD3DRD2ADRA1DMAPT | |
| SCHEMBL10409142 | 0.65 | POLB (0.40) | HTTPOLBMAPT | |
| SCHEMBL10833956 | 0.65 | OPRK1 (0.41) | OPRK1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |